Skills/Expertise
Therassay is a functional exploration core facility for small animals in the field of cardiovascular, metabolic, neuromuscular, digestive, respiratory and cancerous pathologies. Therassay provides to academic and industrial teams technical resources and scientific expertise to analyze new therapeutic pathways in pathophysiology. It is also for the drug or food industry to provide scientific evidence of health effects of their ingredients, extracts or food supplements.
Specific technologies
In vivo tests
- Vascular exploration
- Cardiac exploration
- Pulmonary exploration
- Cancerogenesis
- Motor exploration
- Digestive exploration
Ex vivo
- Isolated organs bath (Gastrointestinal contractility, Cardiac contractility, Contractility of vascular rings on intact or beta-escin permeabilized vascular smooth muscle strips)
- Ussing chamber (Evaluation of paracellular gastrointestinal permeability)
- Isolated working heart
Biochemistry
- Separation of lipoproteins by FPLC
- Sterols and biliary acids analysis in plasma or feces by mass spectrometry analysis (GC/MS)
- Biomarkers quantification
- Haematology
- Luminex® technology
Histology
- Microtom (HS355S)
- Spin tissue processor (STP 120) (Process biological specimens from chemical fixation to paraffin infiltration)
- Coloration baths (x16)
Collaboration modalities
The platform is accessible to academic research units and companies.
- R&D projects and functional exploration in small animals
- Provision of equipments (on line booking, technical support, in course training)
- Value creation, education, animation