Lab of Interdisciplinary chemistery: Synthesis, Analysis, Modelling UMR-CNRS 6230
Repair medicine
Tools for Restorative and Regenerative Medicine

Organization activities


The main idea of all our researches is Molecular Chemistry. The interdisciplinary character of the projects carried out within the laboratory, through its networks of regional partnerships, makes CEISAM a support for 3 poles of activity “Health”, “Agri-food” and “Energy” in Pays de la Loire Region.


CEISAM lab is composed of skills from various fields: fine chemistry (synthesis and methodologies), natural isotopic distributions (measurement &comprehensive approach of the metabolism), hydrogen bond (measurement, modeling & applications), biomaterials, energy, biosensors.


While maintaining strengths in basic,organic/organometallic and analytical chemistries and physicochemistry, CEISAM lab has a transverse strategic positioning in synergy with the Health sector, the Vegetable/Agro-alimentary sector and the topic Materials.


CEISAM has fgained visibility in the following fields

  • photostimulable molecular materials (storage of information, photovoltaic cells with dye, artificial photosynthesis and bioimaging), via an approach of design-development-characterization including the theoretical modelling of the associated electronic processes
  • the biomaterials (combined systems, bone substitute/active ingredients)
  • the analysis and the exploitation of the isotopic effects induced by the metabolism (isotopome) in the living systems
  • the 2 Dimensional ultrafast NMR
  • homogeneous and heterogeneous organometallic catalysis for the development of eco-compatible processes in fine chemicals
  • high level molecular chemistry for health:
    • nuclear medicine around the triptyc Physics/Chemistry/Medicine relying on the cyclotron of high energy “Arronax” (CEISAM is one of the partners of the Equipex “Arronax+” and of Labex “Iron”)
    • Staring from a detailed understanding of the mechanisms of ligands-receptors recognition, the design and synthesis of active molecules targeting cancers, bacterial infections, CNS diseases, and the development of devices for the prediction of the oxydative mechanisms of emergent pollutants (xenobiotic, drugs).


The CEISAM lab is organized in five teams

  • IMF, “Functional Materials Engineering”
  • EBSI, “Elucidation of Biosynthesis by isotopic spectrometry”
  • ModES, “Modelling and Spectroscopy”
  • SYMBIOSE, “Multistep Synthesis & Bioscience”
  • CORAIL, “Catalysis, ORganometallic chemistry And synthesIs of Ligands”


Research activities

Team IMF, “Functional Materials Engineering”

Team leader: Bruno Bujoli – Bruno.Bujoli@univ-nantes.fr



Research themes:

– Interface between chemistry and biotechnologies

– Easily reusable catalysts

– Photovoltaic cells

– Artificial photosynthesis

– Non-linear optical materials

– Methodology in electrochemistry, biosensors

– Electrochemichal transducers made of nanostructured carbon on Silicium support

– Nanomaterials and photoactives molecular films


Team SYMBIOSE, “Multistep Synthesis & Bioscience”

Research themes:


1/ Interface Chimie Biologie (Cancer, SNC, Immunothérapie)

  • Serial synthesis of pluramycines
  • Sugar-induced immunostimulation
  • New bifunctional molecules targeting bones
  • Marine pyran macrocycles
  • IL-15 system agonists and antagonistss synthesis
  • Ion chanels and canceérology
  • Synthesis of Fulvol acetate, a new sesquiterpene presenting a neuroactive action
  • Synthesis and assesment of acetylcholine nicotinic receptor ligands  et évaluation de ligands
  • Nucléotide analogues


2/ Basic researches

  • Radical chemistery
  • Mimicking biological receptors, new supramolecular biological receptors
  • Synthesis of labelled molecules and understanding of their biological mechanism
  • Functionalization pyridazine heterocycles with organobismuth and electrochemistry
  • Synthesis of new polyfunctional molecules for grouped separation of actinides.
  • Synthesis of new oligopyrrolic compounds by cycle regression



Team leaders: Didier Dubreuil and Jacques Lebreton – Didier.Dubreuil@univ-nantes.fr and Jacques.Lebreton@univ-nantes.fr



Team CORAIL, “Catalysis, ORganometallic chemistry And synthesIs of Ligands”

Research themes:

  • Methodologies in organometal chemistry and synthesis
  • Synthesis of biologically active molecules


Team leader: Sébastien GOUIN – Sebastien.Gouin@univ-nantes.fr