Bone sarcoma and remodeling of calcified tissues lab
Repair medicine
Regenerative Medicine
Tools for Restorative and Regenerative Medicine

Organization activities

Our research topics focus on the molecular and cellular mechanisms involved in the development of bone pathologies of tumoral origin (primary bone tumors) or not (vascular calcifications, arthritis, unconsolidated fractures …). Our projects integrate basic research, pre-clinical studies and clinical trials.


Our laboratory, Unité Mixte de Recherche INSERM and Université Bretagne Loire (UMR 1238), consists of 3 research teams:


  • Team 1: Micro environment of primary bone tumours

Signalisation and therapeutic targeting

Team leader: Françoise REDINI –


  • Team 2: Inflammation and cellulars communications in bone pathologies

Team leader: Pierre LAYROLLE  –


  • Team 3: Genetics, epigenetics and cellular stress in bone pathology

Team leader: Benjamin ORY –